Blar i forfatter "Fjalstad, Jon Widding"

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    • Antibiotic Therapy for Neonatal Sepsis - Studies on epidemiology, gentamicin safety, and early adverse effects of antibiotics 

      Fjalstad, Jon Widding (Doctoral thesis; Doktorgradsavhandling, 2018-05-25)
      Objectives: The overall aim of this thesis was to investigate different aspects of antibiotic therapy for neonatal sepsis. Material and Methods: The epidemiology of early onset sepsis (EOS) and systemic antibiotic exposure in the first week of life was studied in a nationwide population-based study from the Norwegian Neonatal Network between 2009-2011. A high-dose extended-interval gentamicin ...

    • Antibiotic therapy in neonates and impact on gut microbiota and antibiotic resistance development: a systematic review 

      Fjalstad, Jon Widding; Esaiassen, Eirin; Juvet, Lene Kristine; van den Anker, John; Klingenberg, Claus Andreas (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-22)
      <p><i>Objectives - </i>To systematically review the impact of antibiotic therapy in the neonatal period on changes in the gut microbiota and/or antibiotic resistance development. <p><i>Methods - </i>Data sources were PubMed, Embase, Medline and the Cochrane Database, supplemented by manual searches of reference lists. Randomized controlled trials (RCTs) and observational studies were included if ...

    • Hearing in schoolchildren after neonatal exposure to a high-dose gentamicin regimen 

      Hemmingsen, Dagny; Mikalsen, Camilla; Rydland Hansen, Alexander; Fjalstad, Jon Widding; Stenklev, Niels Christian; Klingenberg, Claus (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-31)
      <p>OBJECTIVE: To assess the association between gentamicin exposure in the neonatal period and hearing in school age. <p>METHODS: This study included children exposed to a high-dose (6 mg/kg) gentamicin regimen as neonates (2004–2012), invited for follow-up at school age, and a healthy age-matched control group. We assessed hearing with pure tone audiometry including the extended high-frequency ...

    • Neonatal sepsis and the adverse effect of antibiotic treatment - a systematic review 

      Fjalstad, Jon Widding (Master thesis; Mastergradsoppgave, 2015-05-28)
      Abstract Objective: Antibiotic treatment in the neonatal period can be life-saving, but overuse is frequent. Recently studies have shown adverse effects from neonatal antibiotic treatment. This study aims to systematically review the litterature on the relationship between neonatal antibiotic treatment and changes in gut microbiota, the risk of necrotizing enterocolitis (NEC), and the risk of ...